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Description

Furthermore, camphorquinone (CQ), synthesized efficiently via sequential bromination and oxidation of camphor (Maharajan and Cho, 2021), activates the SIRT1/LKB1/AMPK pathway, downregulating ChREBP mRNA while upregulating CES1 and CES2 expression and reducing pro-inflammatory cytokines (IL-1, IL-6, IL-8), thereby alleviating FFA-induced hepatic steatosis and improving lipid metabolism in NAFLD (Maharajan et al., 2025)

2012 Jun 1

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Funding This work was supported by the National Key R&D Program (2016YFD0200305), the Young Elite Scientists Sponsorship Program by CAST (2018QNRC001), the Innovative Research Team Development Plan of the Ministry of Education of China (IRT_17R56) and the Fundamental Research Funds for the Central Universities (KYT201802)

Intracellular ferrous iron (Fe) was measured with an enzyme-linked immunosorbent assay (ELISA)-based kit (Wuhan Elabscience Biotechnology Co., Ltd., China), following cell collection, washing, lysis, and processing as per the manufacturers instructions, with absorbance read at 450 nm