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SARMs bind to androgen receptors in a tissue-specific way, activating anabolic processes in muscle and bone without overstimulating organs like the prostate or liver They do not aromatize into estrogen, which lowers the risk of gynecomastia, bloating, or excess fat gain from water retention SARMs are taken orally , eliminating the need for injections Popular compounds include RAD-140 (Testolone), LGD-4033 (Ligandrol), Ostarine (MK-2866), S23, and YK-11 SARMs were originally developed to treat conditions like cachexia and osteoporosis, with the goal of promoting anabolic effects in muscle and bone while reducing androgenic side effects (Basaria, Journal of Clinical Endocrinology & Metabolism )