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doi: 10.3389/fnagi.2021.650047 72 YanK.ZhangC.KangJ.MontenegroP.ShenJ

The scrambled-shRNA sequence (gttcttctcggtagatgtaataattattacatctaccgagaagaacc) was taken from Surgical procedures For the treatment with Gsto2- shRNA or scrambled shRNA, mutants were randomly selected from ear-notch littermates and assigned to the two experimental groups

we observed a strong growth defect and massive cell death in the LHON-edited cells, but not in the SILENT-edited cells (population doublings per day: LHON 0.64 0.11, SILENT 0.52 0.07

Oxidative stress can lead to oxidative damage of proteins, lipids, and nucleic acids in cells and then death of DA neurons

Not always required for standalone therapy, but we strongly recommend it