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Additionally, delivering ICIs through oncolytic virus carriers proved superior to systemic administration of ICIs ( The accumulation of abnormal metabolites in tumors, as well as typical conditions such as hypoxia, low pH, and oxidative stress, constitute the metabolic microenvironment that impairs the anti-tumor effect of CAR-T

Gashu D, Nalivata PC, Amede T, Ander EL, Bailey EH, Botoman L, et al

Additionally, higher levels of vascular endothelial growth factor, substance P, and platelet-derived endothelial cell growth factor are often detected in the bladder endothelium of IC patients compared to controls Notably, bladder epithelial cells in individuals with IC exhibit intrinsic alterations in differentiation, neurotransmitter release, potassium channel activity, increased nitric oxide production, nuclear factor-B activation, nerve fiber density, serum C-reactive protein levels, and the production of neuropeptide Y and nerve growth factor

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The immune response to this damage, characterized by M1 macrophage polarization, neutrophilic inflammation, and Th17 activation, further exacerbates lipid peroxidation and ferroptosis, creating a vicious cycle that drives disease progression