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398(10317):21602172., Pivotal Phase 2 monotherapy

Eid SA, et al

In addition, it has been reported that TRPA1 is upregulated by NRF2 and enhances tolerance to oxidative stress in tumor cells (Takahashi et al

Although these results appear to contradict previous studies reporting ROS-induced M1 macrophage polarization, they actually reveal the dual role of mtROS under varying dosages and immune environments

Sinomenine (SIN), a bioactive alkaloid derived from Sinomenium acutum , exhibits notable anti-inflammatory, antioxidant, and immunomodulatory properties, and has shown protective effects on the cardiovascular and nervous systems