glutathione reactivity cyano acrylamide The System: A Journey from Cyanobacteria to Higher Eukaryotes Reactivity of Acrylamides Causes Cytotoxicity

GSSG is potentially toxic to the cells but cells normally contain high glutathione reductase activity, which maintain most of the GSH in the reduced form

In fact, it is often called the master antioxidant or the mother of all antioxidants

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Endothelial cell dysfunction may reduce nitric oxide bioavailability and increase reactive oxygen species production, leading to impaired ocular hemodynamics (97), whereas reactive oxygen species can induce cellular senescence and apoptosis (98), which may ultimately lead to optic nerve cell apoptosis, exacerbating optic nerve damage and further exacerbating the progression of glaucoma