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10.1503/cmaj.080282 251 Pasantes-MoralesH.Vzquez-JuarezE

In this non-placebo-controlled trial, eGFR statistically increased after 4 and 8 weeks compared with baseline (2.8 mL/min/1.73 m 2 and 7.2 mL/min/1.73 m 2 at each time point, respectively) [55]

Although tadalafil has received approval from the FDA as a commercial medication for the treatment of ED, BPH, and PAH, it might be used cautiously in subjects at high risk of cerebrovascular ischemic events