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Supplements work best when paired with aggressive rest, strict symptom tracking, and pacing to avoid triggering post-exertional malaise

Cited 2/3/16

It is known that autophagy is defective in dopaminergic neurons in the SN, as observed in post-mortem brains of patients and certain models of PD like 6-OHDA and rotenone-induced models, which show suppression of mTOR, a key enhancer of autophagy (Grassi et al., 2018)