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The GHSRGiscFV16 complex was purified and buffer-exchanged by size exclusion chromatography with buffer containing 20 mM HEPES pH 7.5, 100 mM NaCl, 0.002% MNG, 0.001% CHS, and 1 M ghrelin or ibutamoren

In this randomized, double-blind, multicenter, parallel, placebo-controlled, phase 2b clinical trial, 52 weeks of abatacept treatment reduced RA development over two years compared to placebo