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In three RDP studies, Pycnogenol intake has been shown to act beneficially in patients with osteoarthritis ( A pilot RDP study with 37 patients with joint cartilage damage in the knee from primary osteoarthritis showed that the intake of 150 mg Pycnogenol per day for three months led to relieved joint discomfort, with a significant reduction of 43% in self-reported discomfort, 35% in stiffness and 52% in physical function compared to baseline while placebo controls showed no significant changes ( group, respectively

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Luckily, our bodies produce these built-in defense mechanisms, but if mounting reactive oxygen species (ROS) cannot be neutralized (picture a small fire that grows out of control when gassed with oxygen), damage ensues

Intlekofer AM, Dematteo RG, Venneti S, Finley LW, Lu C, Judkins AR, Rustenburg AS, Grinaway PB, Chodera JD, Cross JR, and Thompson CB