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Among LOX alterations, those of LOX12/15 can lead to oxidative stress, resulting in free radical-dependent DNA damage and poly (ADP-ribose) polymerase-1 overactivation, neuronal degeneration and death (Czapski et al., 2013)

While NETs aid in pathogen control, excessive NETosis can drive immune cell exhaustion and tissue damage (146, 147)

The Role of Oxidative Stress in Infertility

ROS-mediated cell signaling As outlined above, ROS have origin from two main sources: mitochondrial oxidative metabolism and processes of cellular response to xenobiotics, bacteria, and cytokines during which ROS are formed as a part of either signal transduction pathways or a cellular defense mechanism (Finkel 2011)