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3.1.1 Background MDD is characterized by constant depressed mood, anhedonia, altered sleep and appetite, fatigue, guilt, hopelessness, and suicidal tendencies (Arnaud et al., 2022)

Yan J, Li W, Tian H, Li B, Yu X, Wang G, et al

Toldi D, Gyugos M, Dark , Szalai G, Gulys Z, Gierczik K, Szkely A, Boldizsr , Galiba G, Mller M, Simon-Sarkadi L, Kocsy G (2019) Light intensity and spectrum affect metabolism of glutathione and amino acids at transcriptional level

Studies also showed that THC strongly affects rearing activity more strongly than locomotion with tolerance being evident to the latter, but with no recovery of the reduced rearing activity when exposure to THC was continued for weeks (Miczek and Dixit, 1980