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Reperfusion exacerbates injury by generating excessive reactive oxygen species (ROS) and releasing inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-), which drive leukocyte infiltration and microvascular damage

Upon interruption of glutamine metabolism, glutamine-addicted tumor cells employ compensatory anaplerotic mechanisms via pyruvate carboxylase, which generates the oxaloacetate required to maintain TCA cycle flux

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Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers

All chemicals were dissolved in deionized water (DI H2O) without employment of any further purification methods