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GHK-related modulation of matrix metalloproteinase-2 expression

The stratum corneum, located in the most superficial layer of the epidermis, is composed of several to dozens of layers of flat, anucleated keratinocytes attached by the stratum corneum linker, which can resist many environmental stresses while acting as a permeability barrier due to the encapshement of interkeratinocyte lipids

doi: 10.1038/s41416-020-1011-7 81 LeeEQZhangPWenPYGerstnerERReardonDAAldapeKDet al

Abstract Upon exposure to excessive reactive oxygen species (ROS), organismal survival depends on the strength of the endogenous antioxidant defense barriers that prevent mitochondrial and cellular deterioration

These observations not only provided a potential linkage between EBV miRNAs and human malignancy, but also suggested a highly coordinated mechanism through which EBV miRNAs might mimic or compete with human miRNAs to affect cellular functions