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Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

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Another study found a strong association between plasma TNF- levels and KYN as well as KYN/TRP ratios, and patients with higher levels showed greater MDD severity and poor treatment response [104]

An increased interferon gene signature was observed in patients with early RA (eRA), which predicted a poor response to the initial therapies in the first 6 months after diagnosis (8)