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Prolonged ischemic conditions intensify this metabolic disturbance by further reducing ATP levels and intracellular pH, a result of sustained anaerobic metabolism and lactate accumulation

(We refer readers to the regulations at 42 CFR 412.64(m) and to a discussion of the implementation of this provision in the FY 2011 IPPS/LTCH PPS final rule (75 FR 50160 through 50161).) In this FY 2024 IPPS/LTCH PPS proposed rule, we are not proposing any changes to the frontier floor policy for FY 2024

Kobayashi T, Nguyen-Tien D, Ohshima D, Karyu H, Shimabukuro-Demoto S, Yoshida-Sugitani R et al (2021) Human SLC15A4 is crucial for TLR-mediated type I interferon production and mitochondrial integrity