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GIP has been shown to decrease food intake while blunting the metabolic adaptive responses that usually occur with calorie restriction resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids

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T3 (the active thyroid hormone) production can decrease during prolonged dieting as a metabolic adaptation

Types include: Cyanocobalamin stable and widely available Methylcobalamin active form, preferred by some individuals Sublingual drops or sprays helpful for mild absorption issues Injections for significant deficiency In cases where folate deficiency is also present, doctors may recommend folic acid tablets alongside B12 to restore folate levels and ensure the body absorbs and uses both nutrients effectively