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10.1073/pnas.90.24.11825 Proc

Understanding the Evidence: Clinical vs

We identified changes in tissue composition and cellular phenotype associated with cirrhosis

Consistently, HIF1A also promotes GSH synthesis through transcriptional activation of GCLM and SLC7A11 , and pharmacological inhibition of SLC7A11 with erastin or sorafenib exacerbates cuproptosis 177,178