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People with primary insomnia show lower activity of a key antioxidant enzyme and higher signs of oxidative stress compared to healthy sleepers

At increased intestinal barrier permeability, LPS are absorbed into the portal bloodstream, from where they are transported by lipoproteins directly into the liver, forming the gut-liver axis

However, by the time a person enters their 40s, this has slowed to 45 days and continues to slow as they age

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