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Front Cell Dev Biol 9:712834

Metabolomics analysis based on nuclear magnetic resonance (NMR) and mass spectrometry showed that silibinin restrains glucose metabolism to impede the biosynthetic requirements of breast cancer cells and increases levels of BCAAs isoleucine, leucine, and valine, thereby inducing apoptosis in breast cancer (MDA-MB-468, MDA-MB-231, and BT-549) and prostate cancer (PC-3) cells [960, 961]

It is also required for synthesis of nucleic acid, notably DNA, the metabolism of fatty acids and amino acids in the mitochondria, and in delivering SAMe, the universal methyl donor (16) (30)

Ten percent of proceeds from the book will go to Global Lyme Alliance

Genet 48 , 407416 (2016)