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For example, Lactobacillus johnsonii reduces circulating KYN and intestinal IDO activity in rats [185], Bifidobacterium infantis increases plasma TRP and KYNA in male rats [186], and probiotic supplementation in humans lowers plasma KYN while increasing TRP levels [187]

10.3233/JAD-151205 J

Further and comprehensive studies are needed to be carried out to determine the exact inhibition mechanisms of chlorophyllin and to evaluate its possible positive role in metastatic cancer therapy alone or in combination with other anticancer drugs