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Pharmacol Res - Nat Prod 2024:100056

126 ShapiroJ.CohenN

LC3-II and Beclin-1 are key molecules in the autophagy pathway, induction of HO-1 activates the autophagy pathway by increasing the expression of LC3-II and Beclin-1, thereby removing harmful substances from cardiomyocytes [108]

Nonetheless, high-fat diets may negatively impact skeletal health by promoting the gut microbial transformation of dietary L-carnitine into TMAO (166), so disrupting L-carnitines advantageous effects and eventually influencing BMD