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We have identified a family of chloroacetamide-containing compounds with potent inhibitory activity against GSTO1 and efficacy against cancer cells in both in vitro and in vivo models

doi: 10.3389/fnut.2019.00063 108 OConnorT.SadleirK

Foley KP, Ying C, Wang Y, Dai Y, Wang Z, Li J, et al

4 integrates extracellular stress and growth cues to regulate cell-cycle progression, apoptosis, and differentiation, and frequently cooperates with NF-B signaling to promote cancer cell survival and metastasis

Despite these efforts, prospective screening of novel compounds for idiosyncratic DILI potential either in vitro or in vivo remains a challenge, and particularly the immunological aspect of DILI is difficult to model