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Initial burning or stinging upon application typically improves with continued use

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[DOI] [PubMed] [Google Scholar] 37.Li C, Wu B, Li Y, Chen J, Ye Z, Tian X, Wang J, Xu X, Pan S, Zheng Y, et al

Similarly, the oxidation of lipids can lead to the formation of lipid aldehydes, such as 4-hydroxy-2-nonenal (HNE) and malondialdehyde (MDA), that modify proteins to form other stable markers of oxidative stress

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