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It also plays a combined action with the ALC role in 'restoring' the xc-/mGluR2 system, reinstating adequate astrocyte-neuron communication, ultimately mitigating neuro excitotoxicity

Treatment of primary hippocampal cultures Primary hippocampal cultures were treated on DIV5 with 28 nM of AD-tau (concentration determined by total tau sELISA), Con (matched to the total protein concentration of the AD-tau samples), or dPBS vehicle for all seeding experiments with the exception of the PLA experiments in which cultures were treated with 56 nM AD-tau

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Working memory, the cognitive system responsible for temporarily holding information for manipulation, shows particularly consistent improvement