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After treatment, each sample (100 L) was mixed with 40 L of SP3 beads mix (20 L of hydrophobic + 20 L of hydrophilic beads), incubated for 15 min and then overlayed with 1 mL of absolute EtOH

MD simulations also identified a natural compound schisandrin B (Sch B) that specifically bound to the ligand-binding domain of PXR, induced conformational changes and disrupted the PARP1PXR interaction interface, thus suppressed the ribosylation

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