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Hypomethylation of CpG sites within the MSX1 gene reduces its expression, impairing cisplatin-induced apoptosis and p21 activation, thereby promoting cisplatin resistance in HGSC [28]

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This kind of activation promotes tumour -supporting microenvironments and drives metastatic colonization by promoting epithelial-mesenchymal transition and extracellular matrix remodelling [60, 61]