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It can also promote the expression of p21, which competitively binds to the binding site of DNMT1 on the proliferating cell nuclear antigen (PCNA) protein, thus blocking the activity of the PCNA-promoting DNMT1 on hemimethylated DNA (Iida et al., 2010)

Additionally, a higher glycaemic index was associated with an increased risk of oesophageal adenocarcinoma, with each 10-unit increase in glycaemic index amplifying the risk (Reference Mulholland, Cantwell and Anderson75)

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Another study also reported that activation of Nrf2/HO-1 attenuated neuronal injury and depressive-like behaviors, although the BDNF-extracellular regulated protein kinases (ERK)1/2-cAMP-response element binding protein (CREB) axis also contributed to these neuroprotective effects (Zhang J

However, it is always recommended to consult with a healthcare provider before starting any long-term supplement regimen