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In humans, signs of withdrawal include anxiety, depression, and increased sensitivity to stressors 12,13,14 , which are positively correlated with alcohol relapse rates 15,16,17

Different from mainstream studies focusing on the function of AKR1C3 in hormone-dependent cancers, this review pays more attention to hormone-independent cancers and the combined use of AKR1C3 inhibitors and conventional treatment regimens in antineoplastic protocols

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Alternatively, extracellular NAD + can be utilized by NAD + glycohydrolases, generating NAM, NR, or NMN outside of the cells, which can then be transported intracellularly for NAD + synthesis 65,66