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Description

There are two principal signal transduction pathways involving the G protein-coupled receptors: the cAMP signal pathway and the phosphatidylinositol signal pathway

MOTS-C is on the WADA prohibited list as a peptide hormone

Proc Natl Acad Sci USA 2012

33 demonstrated that Gli2 is the key mediator of Shh responses in the skin, and Gli2 controls epithelial cell proliferation in embryonic skin through transcriptional regulation of cyclin D1 and D2, we believed that Shh signaling participated in the process of active hair-follicle density increase through Gli2