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In human plasma, the level of GHK is typically 200 ng/mL at the age of 20, but it declines to 80 ng/mL by the age of 60 [1]

In this context, Hcy serves as a substrate for methionyl-tRNA synthetase (MARS), which catalyzes its conversion into homocysteine thiolactone (HTL), a highly reactive metabolite with enhanced cytotoxicity[14]