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J Biol Chem 285 : 2855328564

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It can keep you up at night or give you the jitters

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but read Ezekiel, for he has drawn those animals approaching from the north

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From what has been mentioned so far, it is very likely that the carcinogenic effect of IDH1 R132 and IDH172 is mediated through the elevated cellular (D)-2HG levels originating from cytoplasm by IDH1 R132 or from mitochondria by IDH2 R172 (where it exits the mitochondria and enters the cytoplasm)

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Farr SA, Poon HF, Dogrukol-Ak D, Drake J, Banks WA, Eyerman E et al (2003)

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