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Feb 2013;10(2):90-99

Research has revealed that acute inhibition of the ERK pathway has inconsistent results in inducing depressive-like behavior, and chronic pharmacological inhibition of ERK through repeated infusion of the specific MAPK kinase (MEK) inhibitor U0126 into the hippocampus and mPFC has been shown to cause depressive-like behavior (Einat et al., 2003

As mentioned, this little powerhouse does occur naturally, but levels decrease as we age

Methods Chemicals INH, RFM, and SLY were purchased from Sigma-Aldrich Co

Functional interplay between collagen network and cell behavior within tumor microenvironment in colorectal cancer