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Knockout of prolyl hydroxylase domain-containing protein 2 (PHD2) stabilized HIF-1 protein and activated HIF-1 signaling, which transcriptionally upregulated glutaminase 1 ( GLS1 ) expression leading to a decrease in ROS production and increases in cellular GSH levels, GSH/GSSG, and cell survival in murine periosteal progenitor cells, suggesting that HIF-1 signaling promotes glutaminolysis to provide glutamate for GSH synthesis (96)

This decrease is probably caused by glutathione-degrading enzymes in S

Costa-Prez, A., Nez-Gmez, V., Baenas, N., et al

Peptides Seg.Id.No: 2,3,4 and 6 were applied in the dosage 8, 25 and 50 mg/kg b.w., i.v