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10.1093/toxsci/kfu040 Toxicol Sci

DOnofrio G, OConnor PG, Pantalon MV, Chawarski MC, Busch SH, Owens PH, et al

For instance, doxorubicin, a topoisomerase inhibitor, induces DNA damage in cancer cells by interfering with topoisomerases and unwinding supercoiled DNA 24