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However, the oncoming proliferation and enlargement of those cells have to be stimulated or enhanced by other factors, especially hormones

At the same time, direct evidence shows that fibroblast migration is modulated through extracellular vesicles derived from macrophages [153], as the vesicles carry a rich cargo of growth factors, cytokines, and microRNAs that can alter the inflammatory milieu, promote angiogenesis, and directly or indirectly stimulate fibroblast proliferation and activation [151,153,154]

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