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Once mature neutrophils enter the systemic circulation, they are able to carry out their functions in the immune response ( New England Journal of Medicine in 2025, demonstrated that brensocatib significantly reduced the annual rate of pulmonary exacerbations and prolonged the time to the first exacerbation compared to placebo ( DPP-1 inhibitors , which act by blocking the maturation and activation of neutrophil serine proteases within the bone marrow, are in different stages of clinical trials