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The conclusions from these essentially negative MR findings have, however, been questioned in a well-argued critique 31 , pointing out the limitations of genetic markers that explain only a small component (i.e., 7.7% at most 5 ) of serum UA variance and querying whether the core assumptions of MR, including the absence of confounds as well as a strong association with UA, are met

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This file in gtf format contains predicted genomic locations for all multi-exonic genes from novel transcript assembly (Methods) that were not associated with genes annotated in release 6.06 of the FlyBase gene model annotation

A parallel study of BFKB8488A in type 2 diabetes patients recapitulated improvements in HDL-cholesterol, triglycerides, and adiponectin, but did not demonstrate improvements in HbA1c, fasting glucose, or fasting insulin (302)