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Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain

A study (48) showed that quercetin could inhibit RANKL production and monocyte-to-osteoclast formation in IL-17-stimulated RA-FLS, inhibit Th17 differentiation and IL-17 secretion, and exert immunomodulatory effects in IL-17-stimulated RA-FLS through mTOR, ERK and NF-B pathways