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In the previously described multicenter retrospective study of over 500 patients, pruritis (3.3%), flushing (2.0%) and urticaria (1.3%) were the most reported symptoms potentially suggestive of anaphylactoid reaction in the IV NAC cohort, with significantly lower rates in the oral cohort [83]

K is a polysarcosine, preferably of the following formula (V) wherein k is an integer between 2 and 50, preferably between 4 and 30, and Re corresponds to OH or NH2

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Receptors protein expression noted in normal dermal fibroblasts Fibroblasts Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules