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An additional reason for not prescribing ACE-inhibitors prior to heart failure is a 2002 Scandinavian study (the "Scandinavian Veterinary Enalapril Prevention [SVEP] Trial") of 229 asymptomatic cavalier King Charles spaniels with mild MVD murmurs, which has has shown that ACE-inhibitors had no significant affect upon the time from the initiation of ACE-I therapy to the point of heart failure (HF)