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Our assessment of a potential therapeutic effect of muscle PGC-1 in dysferlinopathies, leading to an unexpected outcome, has resulted in the discovery of substantial remodeling of muscle metabolism in mice with an ablated dysferlin gene

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Arsenic trioxide combined with TACE prevents extrahepatic metastases and prolongs survival time or improves quality of life in patients with HCC [169,170,171,172,173], and arsenic trioxide injection has shown promising results in the treatment of HCC, with an analgesic effect [168]

Although the results obtained in patients, in various experimental animal or cell models have been inconsistent, taken together the importance of antioxidant enzymes in MASLD development and progression has been clearly shown