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In this review, we highlight the mechanisms by which EVs regulate cellular metabolism, discuss the effects of metabolic state on the production, transport, and function of EVs, and provide an update on the use of EVs in disease diagnosis and engineered targeted therapies

Vitamin A modulates the immune response and maintains homeostasis of epithelial tissues and mucosa through its metabolite, retinoic acid [7]

In addition, the mRNA level of PD-L1 was downregulated in the high-score group, which may indicate that a high SAAM score shows a worse response to ICIs (Figure S6G)

Cells were jointly treated with erastin (2.5 M) cystamine (50 M) for 24 h, and cellular images were captured with a Nikon Eclipse Ti-U inverted microscope (20, scale bar = 30 m)

Phosphate-backbone modification The structural foundation of siRNA typically consists of phosphodiester bonds, which are vulnerable to breakdown by nucleases [65]