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Patients often experience persistent symptoms that are poorly correlated with thyroid hormone levels, an undefined treatment duration, and the need for long-term or definitive therapies

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Kapravelou et al., 2015[70]

Furthermore, computational studies revealed that naringenin showed high binding affinity (9.5 kcal/mol) for collapsin response mediator protein2 (CRMP2), an ADrelated target, along with favorable BBB permeability, reinforcing its druglike properties (Lawal et al