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Targeting specific cell subsets within the profibrotic renal microenvironment, including profibrotic TECs subpopulations and immune cell subsets, particularly profibrotic macrophages, can remodel the renal microenvironment and attenuate fibrogenic signaling

PHH transplantation has been validated as safe in humans, yet major challenges that remain are low efficiency and lack of sustained benefit

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PD-L1 is expressed on tumor cells and controls lifespan of cytotoxic CD8 + T cells when interacting with PD-1 [45]

gossypii (loxPmarker geneloxP cassettes), which allows removing and reusing marker genes as PCR-based targeting tools (Table 3)