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While this study did not explicitly demonstrate a causal relationship between peripheral trauma and de novo parkinsonism, it supports the two-hit hypothesis, i.e., in predisposed individuals (first hit), trauma (second hit) results in increased alpha synuclein oligomerization

[56] showed in their study that total N-acetylaspartate (tNAA) levels lowered in individuals with ASD and Gamma aminobutyric acid (GABA) was associated with communication skills and developmental scores, which are the main symptoms of ASD

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