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Description

Nat Protoc 1 , 31593165 (2006)

Abstract Background Glutathione (GSH), a pivotal non-protein thiol, can be biosynthesized through three pathways in different organisms: (1) two consecutive enzymatic reactions catalyzed by -glutamylcysteine synthetase (Gsh1 or GshA) and glutathione synthetase (Gsh2 or GshB)

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Combining compounds with distinct mechanisms requires careful dose titration and physiological monitoring

In vitro exposure to SeNP can increase levels of H3K4me3, H3K27me3, and H3K9me2 [40], and decrease H3K9me3 methylation [61], imparting a global rather than specific effect on histone methylation