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However, not all studies show benefits roughly half of trials report some improvement, while the other half find no significant effect

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Higher volumes create lower concentrations, making small doses easier to measure

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Human and animal work show that elevations in cytokines, when triggered by infection, exogenous immune stimulation, or sleep deprivation, generally promote increases in total sleep duration, longer non-rapid eye movement (non-REM) sleep duration and increased slow-wave activity, often with concurrent reductions in REM sleep and reduced sleep continuity [1, 4,5,6,7,8]