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ECP and EDN play a role in viral host defense to RNA viruses.51,88,89 New roles for these proteins continue to be identified.90 EDN induces the migration and maturation of dendritic cells.91 It also is an endogenous ligand of Toll-like receptor 2 (TLR2) and can activate myeloid dendritic cells by triggering the TLR2-myeloid differentiation factor 88 (Myd88) signaling pathway.60 Based on its ability to serve as a chemoattractant and activator of dendritic cells along with enhancing antigen-specific Th2-biased immune responses, EDN functions as an alarmin alerting the adaptive immune system to preferentially enhance antigen-specific Th2 responses.60 They are found in the matrices of specific granules in mature eosinophils

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Disruptions in the composition and development of the microbiota during early life have been associated with the severity of lower respiratory tract infections and the onset of chronic inflammatory diseases that begin in childhood

Aging Cell (2019): In aged mice, MOTS-c improved muscle function, endurance, and reduced abdominal fat