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Dependence on skeletal muscle metabolic state

Hydrogenated derivatives thereof A61K31/4418Non condensed pyridines

However, if taking it on an empty stomach causes mild gastrointestinal upset, taking it with a small, light carbohydrate snack can mitigate this issue without severely compromising absorption

For instance, a high acetyl-CoA/CoA ratio in the mitochondrial matrix inhibits pyruvate dehydrogenase (PDH) that catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA (Pietrocola et al., 2015)

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